Study Registry

Taking part in a clinical trial can be a good choice but it is often hard to find a clinical trial that is right for you. Many patient organizations and websites maintain lists of clinical trials. The following table lists some of the clinical trials available worldwide. Please note: this is not an exhaustive list, so please check with your local patient organization. Other trials may be available in your country. If you are aware of an open trial that should be listed here, please send us the trial information to: info@sarcoma-patients.org

Soft Tissue Sarcoma Trials

Trial Name

Subtype

Agents

Phase

Status

Sponsor

Metastatic Leiomyosarcoma (LMS)

Lurbinectedin + doxorubicin

IIb/III

Open, recruiting

PharmaMar

Advanced or metastatic Soft Tissue Sarcoma

Onfekafusp alfa (L19TNF) + Doxorubicin vs. Doxorubicin alone

III

Open, recruiting

Philogen S.p.A.

Advanced Pediatric Solid & CNS Tumors

LOXO-292

I/II

Open, recruiting

Loxo Oncology, Inc. (Eli Lilly)

NTRK-Fusion-Positive Solid Tumors

PBI-200

I/II

Terminated

Pyramid Biosciences

Advanced or Metastatic Soft-tissue Sarcoma

Dacarbazine + L19TNF

II

Open, recruiting

Philogen S.p.A.

Solid tumors incl. soft tissue and bone sarcomas

TNG908

I/II

Open, recruiting

Tango Therapeutics

Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Gene therapy: ADP-A2M

II

Open, recruiting

Adaptimmune

Solid tumors incl. soft tissue and bone sarcomas

TNG462

I/II

Open, recruiting

Tango Therapeutics

Leiomyosarcoma & Liposarcoma

Preoperative chemotherapy & surgery

III

Open, recruiting

EORTC

Epithelioid Sarcoma

Tazemetostat + doxurubicin vs. docurubicin + placebo

III

Open, recruiting

Epizyme Inc.

Extremity Soft Tissue Sarcomas

Preoperative Radiotherapy

II

Open, recruiting

The Netherlands Cancer Center

Liposarcoma

BI 907828

III

Closed for recruitment, but active

Boehringer Ingelheim

Bone Sarcoma Trials

Trial Name

Subtype

Agents

Phase

Status

Sponsor

Conventional chondrosarcoma

INBRX-109 vs. placebo

II

Open, recruiting

Inhibrx, Inc.

Ewing's sarcoma

Different chemotherapy regimens

II/III

Open, recruiting

University of Birmingham

Osteosarcoma

Cabozantinib

II

Open, recruiting

Ipsen

Conventional chondrosarcoma

Ivosidenib vs. placebo

III

Open, recruiting

Servier Bio-Innovation LLC

Ewing Sarcoma / Pediatric Patients

Palbociclib in combination with chemotherapy

II

Open, recruiting

Pfizer

Ewing's sarcoma, Chondrosarcomas, Osteosarcomas, Chondromas

Regorafenib vs. placebo

II

Open, recruiting (France only)

UNICANCER

Ewing's Sarcoma

Abemaciclib (LY2835219) + Irinotecan + Temozolomide

II

Open, recruiting

Eli Lilly and Company

Solid tumors incl. soft tissue and bone sarcomas

TNG908

I/II

Open, recruiting

Tango Therapeutics

Solid tumors incl. soft tissue and bone sarcomas

TNG462

I/II

Open, recruiting

Tango Therapeutics

GIST Trials

Trial Name

Subtype

Agents

Phase

Status

Sponsor

Advanced GIST

CGT9486 (Bezuclastinib) and Sunitinib

III

Open, recruiting

Cogent Biosciences, Inc.

Advanced GIST

IDRX-42

I

Open, recruiting

IDRx Inc

Advanced GIST

Ripretinib vs. Sunitinib

III

Open, recruiting

Deciphera Pharmaceuticals

KIT/PDGFR wild type GIST

Regorafenib

II

Open, recruiting

Grupo Espanol de Investigacion en Sarcomas

Operable GIST

Imatinib

III

Closed for recruitment, but active

Scandinavian Sarcoma Group (SSG)

Desmoid / TGCT Trials

Progressing Desmoid Tumors

AL 102 vs. placebo

II/III

Active, but not recruiting

Ayala Pharmaceuticals, Inc.

Desmoid Tumor/Aggressive Fibromatosis

Nirogacestat

III

Closed for recruitment, but active

SpringWorks Therapeutics, Inc.

Tenosynovial Giant Cell Tumor (TGCT)

Vimseltinib

III

Closed for recruitment, but active

Deciphera Pharmaceuticals LLC

Tenosynovial Giant Cell Tumor

Pimicotinib (ABSK021)

III

Closed for recruitment, but active

Abbisko Therapeutics Co, Ltd

The Desmoid Tumour Research Foundation has a extensive list of further ongoing, mostly mono-country clinical trials for patients with desmoid tumour/aggressive fibromatosis. Please find it here.

 

National trial registries

Some of our SPAGN member groups run clinical trial registries to inform about national and international trials in their respective countries.
Browse here to find out more:

Is your rescource missing on this list? Please let us know and send an email to info@sarcoma-patients.org.